Hydroxamic acids tuaj yeem npaj los ntawm cov tshuaj tiv thaiv ncaj qha ntawm carboxylic acids nrog hydroxylamine. Txoj kev no feem ntau yog ua raws li acidic los yog yooj yim tej yam kev mob; cov carboxylic acid muab cov pab pawg carbonyl, thaum cov hydroxylamine muab cov -N-OH moiety, yielding cov hydroxamic acid ntawm ib tug nucleophilic ntxiv cov tshuaj tiv thaiv. Kev ua haujlwm, nws yog ib qho tsim nyog los tswj cov tshuaj tiv thaiv kub thiab noo noo kom tsis txhob muaj kev cuam tshuam sab nraud thaum ua kom ntseeg tau cov txiaj ntsig thiab purity ntawm cov khoom. Lwm txoj kev ua haujlwm feem ntau suav nrog cov tshuaj tiv thaiv ntawm acyl halides nrog hydroxylamine. Nyob rau hauv txoj kev no, carboxylic acid yog thawj zaug hloov mus rau hauv acyl halide, uas tom qab ntawd reacts nrog hydroxylamine los tsim cov hydroxamic acid. Txoj kev no yog tus cwj pwm los ntawm cov tshuaj tiv thaiv sai dua, kev tawm tsam tsawg dua, thiab ntau dua yields. Kev lag luam, txoj kev no tau siv ntau zaus vim nws cov tshuaj tiv thaiv me me thiab cov txiaj ntsig zoo ib yam, ua rau nws zoo - haum rau loj - nplai ntau lawm.
Xwb, hydroxamic acids tuaj yeem tsim los ntawm cov tshuaj tiv thaiv ntawm carboxylic acid esters nrog hydroxylamine-ib txoj hauv kev hu ua transesterification. Txoj hauv kev no yog qhov tshwj xeeb tshaj yog rau cov dej noo- cov txheej txheem rhiab heev, raws li nws hla qhov teeb meem ntawm cov dej noo tsis zoo cuam tshuam rau cov khoom lag luam tawm los, muaj peev xwm cuam tshuam ntawm txoj kev ncaj qha carboxylic acid. Los ntawm kev ua tib zoo xaiv cov kuab tshuaj uas tsim nyog thiab cov tshuaj tiv thaiv qhov kub thiab txias, txoj kev transesterification ua rau kev tsim cov siab -purity hydroxamic acids; yog li ntawd, nws yog dav siv nyob rau hauv ob qho tib si chaw kuaj thiab cov tshuaj lom neeg kev lag luam zoo.
